Planificación pre-operatoria digital en artroplastia total de cadera / Digital templating in total hip arthroplasty

Introducción: La planificación preoperatoria favorece la realización de un acto quirúrgico sin complicaciones. Actualmente existe escasa información a nivel nacional sobre la eficacia de la planificación pre-operatoria digital por lo que el objetivo del presente estudio es el analizar los resultados de la implementación de esta estrategia en una población de pacientes con indicación de artroplastia total de cadera. Materiales y métodos: Estudio observacional, prospectivo, analítico. Se realizó un muestreo no probabilístico de casos consecutivos atendidos en la Cátedra de Ortopedia y Traumatología de la Facultad de Ciencias Médicas (U.N.A). Fueron captados pacientes >18 años con indicación de ATC, entre diciembre 2018 ­ octubre 2019, previo consentimiento informado. Se relevaron datos cuya caracterización fue posible mediante un instrumento establecido previamente, ingresado en base Excel. Se utilizó el software TraumaCad® versión 2.5 de Brainlab y marcadores radiológicos King Mark®. Fueron comparados ambos tipos de planificación ejecutando análisis estadísticos con el software R.v3.4.2., siendo un valor p ˂0.05, considerado estadísticamente significativa. Resultados: 57 pacientes fueron evaluados con el método digital y los resultados fueron comparados con los de 42 pacientes en los que se utilizó una planificación manual. La relación masculino-femenino fue 1/1, siendo los del grupo de 50 a 60 años, los más afectados. La coxartrosis primaria y la necrosis ósea aséptica fueron los diagnósticos más frecuentes. El tiempo quirúrgico, la correlación entre planificación y resultados para componentes acetabular, femoral, presentaron mejores resultados en el grupo de pacientes con planificación digital. Conclusión: La planificación digital comparada con la manual presentó mayor eficacia.

Introduction: Preoperative planning allows a surgical act without complications. It can be manual or digital. Its usefulness in total hip arthroplasty (ATC) is important, being digital seemingly more beneficial since it reduces surgical time and complications. The present study analyzed the effectiveness of the digital modality. Materials and methods: Observational, prospective, analytical study. Non-probabilistic sampling of consecutive cases attended in Department of Orthopedics and Traumatology of the Medicine Scholl (Universidad Nacional de Asunción). Patients> 18 years of age were indicated with ATC indication, between december 2018 to october 2019, with prior informed consent. Data whose characterization was made possible by means of a previously established instrument, entered in Excel basis, were released. Each patient had both types of planning: manual and digital. For TraumaCad® version 2.5 Brainlab software and King Mark® radiological markers were used for the digital. Both types of planning were compared by executing statistical analyzes with the software R.v3.4.2., being a value p <0.05, considered statistically significant. Results: 57 patients were evaluated with the digital method and 42 with the manual. The male-female ratio was 1/1, with those in the 50-60 age group being the most affected. The most frequent reason for consultation was hip pain, with primary coxarthrosis and aseptic bone necrosis being their cause. The consultation time 1 and surgery was 12.5 days. The surgical time, the correlation between planning and results for acetabular, femoral components, were more effective with digital planning. Conclusion: Digital planning compared to the manual is more effective.

Characterization of the genetic structure of mango ginger (Curcuma amada Roxb) from Myanmar in farm and genebank collection by the neutral and functional genomic markers

A preliminary characterization was undertaken to describe genetic structure of mango ginger (Curcuma amada) acquired from farmers and ex situ genebank in Myanmar using neutral (rice SSR based RAPDs) and functional genomic (P450 based analog) markers. The high polymorphism (> 91 percent) depicted has displayed existence of genetic variability in the germplasm investigated. Large number of source-specific alleles (neutral-markers = 78, functional-markers = 63) was amplified which revealed that neutral regions of the mango ginger were more variable compared with the functional regions. The major fraction of the molecular variance (neutral-markers = 85 percent, functional-markers = 93 percent) was explained within germplasm acquisition sources and this tendency was also supported by the estimate of gene diversity. The genebank accessions have shown comparatively more genetic variability than farmers' accessions. The variability observed in mango ginger may possibly be associated with the long history of its cultivation under diverse ecological conditions. The two marker systems elucidated their high resolving power which detected variability even in fewer genotypes assayed. As the target sites of these markers are different, therefore, the variability detected is believed to cover diverse part of the genome together with neutral and functional regions. We found the concurrent use of the different types of molecular markers valuable to comprehend a dependable variability pattern in the germplasm assayed.